Sickle Cell

This groundbreaking book chronicles the history of sickle cell anemia in the United States, tracing its transformation from an "invisible" malady to a powerful, yet contested, cultural symbol of African American pain and suffering. Set in Memphis, home of one of the nation's first sickle cell clinics, "Dying in the City of the Blues reveals how the recognition, treatment, social understanding, and symbolism of the disease evolved in the twentieth century, shaped by the politics of race, region, health care, and biomedicine. Using medical journals, patients' accounts, black newspapers, blues lyrics, and many other sources, Keith Wailoo follows the disease and its sufferers from the early days of obscurity before sickle cell's "discovery" by Western medicine; through its rise to clinical, scientific, and social prominence in the 1950s; to its politicization in the 1970s and 1980s. Looking forward, he considers the consequences of managed care on the politics of disease in the twenty-first century. A rich and multilayered narrative, "Dying in the City of the Blues offers valuable new insight into the African American experience, the impact of race relations and ideologies on health care, and the politics of science, medicine, and disease.

Chronicles the history of sickle cell anemia in the United States as it was witnessed in Memphis, where the first sickle cell clinics were founded in the 1950s, and traces the impact of awareness, medical development, and politics on treatment. Simultaneous.

Sickle-cell disease - Sickle cell disease is a general term for a group of genetic disorders caused by sickle hemoglobin (Hgb S). In many forms of the disease, the red blood cells change shape upon deoxygenation because of polymerization of the abnormal sickle hemoglobin.

Cell cycle checkpoint - Cell cycle checkpoints exist at specific points in the cell cycle in eukaryotic cells to prevent them from progressing to the next phase of the cell cycle in the event of DNA damage or another condition which would make cell division dangerous for the cell. Feedback from the cell about its size and condition of its chromosomes determines whether the cell cycle does or does not progress; the feedback can either trigger subsequent phases or delay them to allow time for ...

Hemoglobinopathy - Hemoglobinopathy is a kind of genetic defect that results in abnormal structure of one of the globin chains of the hemoglobin molecule. It is a collection of a number of diseases, including sickle-cell disease and thalassemia.

Autosplenectomy - An autosplenectomy occurs when a disease damages the spleen to such an extent that it is non-functioning and so equivalent to the spleen having been surgically removed (splenectomy). This may occur in sickle-cell disease and spherocytosis.

sicklecell

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